631,457 markers. One plan.

The most common genotype. Average late-onset Alzheimer and lipid risk — not ε4, not ε2.

ε4 (rs429358 C) is the well-known Alzheimer and CHD risk allele. ε2 (rs7412 T) is associated with lower Alzheimer risk and a different lipid pattern. This genome is ε3/ε3. That is not protective like ε2, and it is not the elevated-risk ε4 genotype. Microarray cannot see rare APOE coding changes or APP/PSEN mutations.

One copy of SLCO1B1 c.521T>C. Higher myopathy risk on high-dose simvastatin.

CPIC and the FDA label treat this as decreased OATP1B1 function. Heterozygotes have several-fold higher risk of simvastatin-related muscle injury at 80 mg, and a smaller increase at 40 mg. Atorvastatin, pravastatin, rosuvastatin, and fluvastatin are preferred if a statin is indicated. This does not mean you cannot take a statin — it means the drug and dose should be chosen with this genotype in mind.

If a statin is ever prescribed, prefer non-simvastatin agents or keep simvastatin at a low dose. Mention this result to the prescriber.

One copy of the MUC5B promoter variant. Raises idiopathic pulmonary fibrosis risk, still a rare disease.

The T allele is the strongest common genetic risk factor for IPF (roughly 4–8× in heterozygotes). Lifetime risk remains on the order of about 1% in carriers versus ~0.2% in non-carriers — most people with this genotype never get IPF. Carriers who do develop IPF tend to have better survival than non-carriers. Smoking, agricultural dust, and reflux amplify risk. This is a reason to take unexplained chronic dry cough or breathlessness seriously, not a diagnosis.

Do not smoke. Avoid concentrated organic/agricultural dust. Treat reflux. Stay current on influenza, COVID, and pneumococcal vaccines. See a clinician for unexplained dry cough lasting weeks.

Heterozygous for the T allele. Modest but well-replicated increase in type 2 diabetes risk.

TCF7L2 rs7903146-T is the largest-effect common variant for T2D in European-ancestry GWAS (roughly 1.4× per T allele). It affects incretin signaling and insulin secretion, not just BMI. Combined here with one FTO risk haplotype, the genetic nudge is real but still smaller than body weight, fitness, and diet. Lifestyle change has repeatedly been shown to blunt this risk.

Worth a baseline fasting glucose or HbA1c with a clinician. Resistance training and fiber-rich meals pay extra dividends with this genotype.

Two functional R alleles. Fast-twitch fibers express α-actinin-3. Sprint / strength biased.

The X allele (T) prematurely stops the protein. XX is over-represented in endurance elites; RR is over-represented in power sports. RR is the most common genotype worldwide. It is a training hint: this genome should respond well to heavy resistance and high-intensity intervals. It does not make anyone an athlete by itself.

Bias training toward strength and power if the goal is physique or sport. Endurance is still fully trainable.

European −13910T is present. Adult milk digestion should be intact.

rs4988235 G is the European persistence allele (plus-strand). Heterozygotes persist. rs182549 T is on the same European haplotype. This does not rule out secondary lactose intolerance after gastroenteritis.