What this genome is asking you to do.

If a clinician ever starts a statin, this genome is a SLCO1B1*5 heterozygote. Simvastatin at high dose is the one to avoid. Atorvastatin, rosuvastatin, or pravastatin are the usual work-arounds. This is a CPIC-backed interaction, not a wellness guess.

SLCO1B1 rs4149056 C/T

One MUC5B promoter T allele raises idiopathic pulmonary fibrosis risk. The disease is still uncommon. The useful moves are boring and high-leverage: do not smoke, do not vape, avoid concentrated farm or compost dust, treat chronic reflux, and do not ignore a dry cough that lasts weeks.

MUC5B rs35705950 G/T

PEMT 175M/M means the liver makes phosphatidylcholine poorly. Two eggs most days covers a large share of the AI. Liver, meat, soy lecithin, or a choline bitartrate / CDP-choline supplement are backups if the diet is plant-forward.

PEMT rs7946 T/T

Ask a clinician for: fasting lipids + Lp(a) once, HbA1c or fasting glucose, ferritin + transferrin saturation, 25-OH vitamin D, and (optional) homocysteine with B12 and folate. None of these genotypes diagnose a disease. They tell you which numbers are worth knowing.

TCF7L2, FTO, 9p21, H63D, methylation stack

ACTN3 RR responds well to heavy resistance and sprints. TCF7L2 and FTO make muscle and fiber unusually valuable for glucose control. A practical split: 3 lifting sessions + 1–2 short intervals + daily walking. That pattern matches this genome better than long slow cardio alone.

ACTN3 RR + TCF7L2 CT + FTO het

9p21 is lipid-independent. Blood pressure, not smoking, sleep, and cardiorespiratory fitness move this risk more than any supplement. Know the numbers: BP, ApoB or LDL, and that once-only Lp(a).

9p21 heterozygous

CYP1A2 *1F/*1F clears caffeine quickly. The slow-metabolizer coffee–MI story does not apply. Stop caffeine 8 hours before bed anyway if sleep is the goal. Lactase persistence means dairy in the coffee is fine.

CYP1A2 AA + LCT persistent

Intermediate FADS conversion plus a PEMT-limited phospholipid pathway is a quiet argument for actual long-chain omega-3s rather than flax-only.

FADS het + PEMT TT

SLC24A5, SLC45A2, and HERC2 G/G describe a low-melanin iris and skin. Use sunscreen on long exposure. The vitamin D SNPs are favorable, so deficiency is more about indoor life than genes.

Pigmentation cluster

CYP2C19 normal. CYP2C9 normal. VKORC1 higher-dose haplotype. SLCO1B1 intermediate (avoid high-dose simvastatin). TPMT/DPYD common alleles normal. HLA-B*5701 tag negative. CYP2D6 possibly *3 carrier — confirm before tamoxifen or codeine if those drugs appear.

CPIC-relevant star alleles on the chip

Common BRCA, Lynch, and familial-hypercholesterolemia variants are mostly absent from 23andMe v5, and indel encodings are easy to misread. If a parent or sibling had early breast, ovarian, colorectal, or very high LDL, see a genetic counselor. Do not treat a quiet microarray as a negative clinical test.

Assay limits, not a genotype

Y is R1a-L260 (West Slavic). mtDNA is J1c. A Big Y or full mitochondrial sequence will split those into modern subclades and match living testers. Autosomal AIMs already say Northwest/Central European — an imputation-based ancestry tool (e.g. a research PCA) would add percentages, not a new story.

R1a-L260 + J1c + European AIMs