A European methylation stack, not a syndrome.

The high-impact C677T variant is absent. Both copies of A1298C are present — a milder reduction in MTHFR activity.

23andMe reports the plus strand: rs1801133 G = coding C (no 677T); rs1801131 G = coding C (1298C). Homozygous 1298C retains more enzyme activity than 677TT (roughly 60% vs ~30%). It can contribute to higher homocysteine when folate, B12, or B6 are low, especially stacked with heterozygous MTR, MTRR, MTHFD1, and BHMT here. It is not a disease and does not require prescription methylfolate by default.

Eat leafy greens and adequate animal or fortified B12. Optional: homocysteine + B12 + folate labs if there is a clotting, pregnancy, or neuropathy story.

Homozygous for the reduced-function PEMT allele. The body is less efficient at making phosphatidylcholine.

PEMT synthesizes phosphatidylcholine in the liver. The 175M variant lowers that capacity. Effect is largest in premenopausal women (estrogen induces PEMT), but men still rely on dietary choline when PEMT is sluggish. Low choline is linked to fatty liver and muscle damage in depletion studies. Eggs, liver, meat, soy lecithin, and crucifers are the practical fix.

Make choline-rich foods a default (eggs most days, or a choline supplement if plant-based). This pairs with the methylation stack above.

European −13910T is present. Adult milk digestion should be intact.

rs4988235 G is the European persistence allele (plus-strand). Heterozygotes persist. rs182549 T is on the same European haplotype. This does not rule out secondary lactose intolerance after gastroenteritis.

ALDH2*2 and ADH1B*2 are both absent. Typical European alcohol-metabolism pattern.

No built-in acetaldehyde dump (ALDH2*2) and no super-fast ADH1B*2. Alcohol is still a toxin; this genotype just means the East Asian flush-and-protection package is not in play. Standard cancer and liver guidance applies.

GC rs2282679 is T/T (higher 25-OH-D). CYP2R1 rs10741657 is A/A (higher). DHCR7 is T/T.

These are the largest-effect common SNPs for circulating 25-hydroxyvitamin D. The genotype cluster leans toward higher levels than average for European ancestry. Latitude, time indoors, and skin pigmentation still dominate. VDR BsmI and TaqI are heterozygous — receptor SNPs with mixed, smaller literature.

One reduced-import MnSOD allele. Common. Antioxidant capacity is intermediate.

The Val allele (A on plus strand for this SNP in many chips; here A/G) impairs mitochondrial targeting of MnSOD. Heterozygotes are the majority in Europe. GSTP1 I105 is A/A (Ile/Ile, wild-type). NQO1 P187S looks wild-type. No dramatic detox genotype.

Heterozygous at the FADS haplotype that converts plant omega-3/6 into EPA/AA.

Derived European haplotypes convert linoleic and alpha-linolenic acid more efficiently. Heterozygotes sit in the middle. If the diet is mostly plant omega-3 (flax, chia), preformed EPA/DHA from fish or algae is the more reliable path.

Prefer fatty fish a couple of times a week, or an algae/fish oil if the diet is plant-heavy.

Functional FUT2. Secretor status. Higher average B12; can bind norovirus in the gut.

The W143X non-secretor allele (A at rs601338) is absent. Secretors present H antigen in mucosa, which norovirus uses as a receptor, and they tend to have higher serum B12 than non-secretors. Neither is destiny for infection or deficiency.

Heterozygous at R267S. Plant vitamin A is converted a bit less efficiently.

People with reduced BCO1 function make less retinol from beta-carotene. Preformed vitamin A (liver, dairy, eggs) or a mixed diet covers it. This is a small effect.

One variant each at MTR A2756G, MTRR A66G, MTHFD1 G1958A, BHMT, and CBS C699T.

Individually these are common European polymorphisms. Together with MTHFR 1298C/C and PEMT 175M/M they describe a folate–choline–B12 pathway that prefers a solid diet over a processed one. CBS C699T is often treated as an up-regulator (lower homocysteine). This is a nutrition pattern, not a syndrome, and it is the main reason Genetic Genie-style reports look “busy” for many Europeans.

Food first: greens, eggs, meat or B12-fortified foods. Skip high-dose niacin or unguided methyl-folate megadoses.